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Transparent Growth Measurement (NPS)

Industry: HealthTech

Helping a Tokyo-based regenerative medicine clinic explore and develop the Indian market through data-led Google advertising, indication-level targeting, and premium international positioning.

From Market Validation to Patient Acquisition: Building a Digital Growth Engine for HELENE Clinic in India

brief
Stemcells Story

HELENE Clinic, a regenerative medicine and healthcare provider based in Tokyo, Japan, wanted to explore the Indian market’s potential for international patient acquisition. While India has a large healthcare market and growing interest in advanced medical treatments, Indian patients also have access to local stem cell providers, making international travel a significant consideration.

The initial challenge was therefore not simply generating leads. HELENE needed to understand whether there was genuine demand in India for its regenerative treatment programs, which treatment areas showed the strongest potential, what patients were searching for, and whether Indian prospects would consider travelling to Japan for treatment.

upGrowth began with a market validation pilot and then moved into a second phase focused on acquiring qualified patients. Over the engagement, the strategy evolved based on search behaviour, campaign performance, audience quality, healthcare advertising restrictions, and the growing need to differentiate HELENE from locally available treatment providers.

Identified
Identified Challenges
  • No established digital patient-acquisition channel in the Indian market.
  • Abundant local stem cell and regenerative medicine providers.
  • Significant barrier of international travel for Indian patients.
  • Need to identify treatment indications with genuine search demand.
  • Healthcare advertising restrictions limited available keywords and audience-targeting options.
  • Broad prospecting campaigns generated high volumes but lower-quality inquiries.
  • Long consideration cycle for high-value medical tourism decisions.
  • Need to establish why patients should choose Japan over locally available alternatives.
  • Limited progression from initial inquiries to medical-record submission.
  • Need to reach affluent/high-value audiences without excessively restricting campaign reach.
empathy, research
upGrowth's Strategy and Execution

Scope of Engagement

upGrowth managed the digital acquisition program across Google Search and Display, with ongoing strategy, optimisation, reporting and testing.

Key Initiatives

  • India market and keyword research
  • Google Search campaign strategy and execution
  • Indication-level campaign and ad-group structuring
  • High-intent keyword expansion based on search-term data
  • Negative keyword strategy and ongoing search-term optimisation
  • HNWI audience testing
  • Geographic and device-level optimisation
  • Landing page strategy and CRO recommendations
  • Ad copy development and creative iteration
  • Google Display and Performance Max testing
  • Search remarketing testing
  • WhatsApp conversation tracking 
  • Weekly performance reporting
  • Monthly strategic reviews and optimisation recommendations

 

Initial Situation

At the start of the engagement, HELENE lacked an established India acquisition funnel and needed data to determine whether Indian patients would consider travelling to Japan for regenerative treatment.

The engagement began with a market validation phase, designed to identify:

  • Search demand
  • Treatment-level interest
  • Acquisition costs
  • Lead quality
  • Audience response
  • Early signals of international patient interest

 

Phase 1 identified Osteoarthritis and Type 2 Diabetes as the strongest areas for continued testing.

Phase 2 then moved towards improving lead quality, premium-audience testing, stronger Japan differentiation, and more focused high-intent acquisition.

 

The Objective

Validate the Indian market and identify a viable pathway for international patient acquisition.

The key objectives were to:

  • Identify genuine demand for regenerative treatment in India.
  • Determine which treatment indications demonstrated the strongest interest.
  • Understand acquisition costs and campaign efficiency.
  • Test premium/HNWI-oriented audience strategies.
  • Build stronger differentiation around treatment in Japan.
  • Improve inquiry quality rather than simply increase lead volume.
  • Understand whether digital engagement could progress towards real patient journeys.

The upGrowth Strategy

1. Start With Market Validation

Rather than assuming which treatment areas would work in India, we used search behaviour and campaign data to identify demand by indication.

The initial focus covered multiple treatment areas, and performance data later helped narrow it to Osteoarthritis and Type 2 Diabetes.

 

2. Move From Generic to High-Intent Search

Generic stem cell searches can attract a wide range of users, including research-oriented traffic.

We therefore shifted towards more specific search intent, including:

This helped create stronger alignment between user intent, ad messaging and landing-page content.

 

3. Test Premium Audience Positioning

Because HELENE’s proposition is international and premium, we tested an HNWI-focused Osteoarthritis campaign using available audience signals, including higher household-income segments and selected premium behavioural signals.

The objective was to understand whether a more premium audience could generate stronger-quality engagement without excessively limiting reach.

 

4. Build a Stronger “Why Japan?” Proposition

The campaign evolved from simply promoting regenerative treatment to answering a more important question:

Why should an Indian patient consider travelling to Japan?

Messaging increasingly focused on:

This helped differentiate HELENE from local treatment providers without competing primarily on price.

 

5. Test, Learn and Optimise

Google Search remained the primary high-intent acquisition channel.

We also tested Display and Performance Max to evaluate incremental reach. However, broader automated campaigns produced a higher proportion of low-quality or spam inquiries, based on client feedback, so we tightened controls and focused more on high-intent Search.

Campaign performance was continuously reviewed across:

The strategy was continuously refined based on these learnings.

 

Impact

Campaign Highlights

Across the engagement, the campaigns generated approximately:

The campaign generated measurable demand from Indian users and established clear indication-level search patterns, particularly around Osteoarthritis and Type 2 Diabetes.

Patient Outcome

One Indian patient who had interacted with the clinic in June subsequently travelled to Japan, visited HELENE Clinic and completed treatment. Based on client feedback, the patient was influenced by the digital campaigns and was specifically interested in anti-ageing treatment.

While this represents one patient outcome and cannot be attributed solely to paid advertising, it provided an important real-world signal that the digital activity could contribute to an international patient journey.

 

Strategic Learnings

Search Intent Was More Valuable Than Broad Reach

Condition-specific, treatment-oriented searches generated clearer intent than broad awareness campaigns.

Osteoarthritis and T2DM Emerged as Key Demand Areas

These two indications demonstrated the strongest and most consistent search interest during the engagement.

Alternative-Treatment Messaging Resonated

Themes such as:

performed strongly and provided useful signals for future acquisition strategy.

Premium Positioning Requires a Clear Reason to Travel

Affluent audiences alone are not sufficient. The proposition must clearly communicate why a patient would choose a Japanese provider instead of a local Indian option.

Healthcare Restrictions Affect Acquisition Economics

Healthcare advertising restrictions limited keyword and audience expansion and contributed to a more constrained and potentially higher-cost acquisition environment.

The Real Challenge Is Patient Progression

Generating clicks and inquiries was achievable, but moving users from an initial inquiry to medical-record submission and treatment required significantly more trust and consideration.

Conclusion

The engagement helped HELENE move from an initial question – “Is there demand for regenerative treatment from India?” – towards a clearer understanding of where that demand exists and how Indian patients respond to an international treatment proposition.

The market demonstrated genuine interest, particularly around Osteoarthritis and Type 2 Diabetes, while search data provided valuable insights into treatment intent, geographic demand and messaging preferences.

At the same time, the engagement highlighted the complexity of international medical acquisition. Generating interest is only the first step; establishing trust, clearly communicating the value of treatment in Japan, and supporting the patient through a longer decision journey are essential to converting interest into treatment.

For HELENE, the key opportunity is therefore not simply to increase traffic, but to build a differentiated Japan-based regenerative medicine proposition supported by high-intent acquisition, stronger content, trust-building and a patient journey designed specifically for international patients.

Testimonials

Untitled Design 6
Helene

We weren’t sure if Indian patients would even consider travelling to Japan for treatment. upGrowth helped us find out with real data, not guesswork. They showed us where the demand was and helped us explain why Japan is worth the journey. Seeing our first patient from India visit the clinic was a proud moment for us.

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